Proteoglycan Replacement Therapy

 

Proteoglycan Replacement Therapy involves the oral administration of bioavailable proteoglycans designed to increase the concentration of key hair follicle proteoglycans – Versican, Syndecan, and Decorin –  essential for promoting healthy hair growth.

 

Proteoglycan Replacement Therapy is a therapeutic intervention that gradually reverses Proteoglycan Follicular Atrophy through five distinct stages.

1Atrophied Follicle

When a hair follicle enters the stage of atrophy, it means the follicle has ceased functioning and can no longer produce a hair strand. At this point, the follicle is considered dead.

 

Hair transplantation becomes the only viable treatment option once a follicle has reached this stage. It is therefore vital that Proteoglycan Replacement Therapy is introduced in the earlier stages of the Hair Growth Cycle.

2Severe Hypo-Glycania

It is crucial that proteoglycan levels in the hair follicle are restored before atrophy occurs, and no later than the stage of severe Follicular Hypo-Glycania.

 

With the introduction of Proteoglycan Replacement Therapy, proteoglycan levels begin to rise, and the follicle starts to exit its current state of severe Follicular Hypo-Glycania.

3Mild Hypo-Glycania

As proteoglycan levels continue to rise, the follicle begins to emerge from its dormant state. The follicle exits its state of severe Hypo-Glycania and enters a milder state of Hypo-Glycania.

 

In this new state, early signs of metabolic recovery appear, laying the groundwork for follicular reactivation and renewed growth.

 

4Dysregulated Follicle

With continued use of Proteoglycan Replacement Therapy, proteoglycan levels rise above the critical threshold, resolving cellular starvation. The follicle exits its state of mild Hypo-Glycania and enters a state of minimal dysregulation.

 

At this stage, the duration of the Telogen (resting) phase normalises, ultimately leading to reactivation of the previously dormant follicle.

5Healthy Growing Follicle

With a fully restored proteoglycan balance, the hair follicle returns to a normal, healthy state.

 

This re-establishes the normal Hair Growth Cycle, bringing back a balanced environment in the follicle that ensures the hair remains in the Anagen (growth) phase for the full duration and reduces the risk of premature shedding.

Nourkrin®, with the unique Marilex®, is a scientifically developed Proteoglycan Replacement Therapy that promotes the Hair Growth Cycle by normalising and maintaining the life and function of the hair follicles.

Stabilising the Hair Growth Signal with PRT

1Cycle 1

Proteoglycan Replacement Therapy is an intervention that restores proteoglycan levels in the dermal papilla, hereby restoring the structural integrity of the follicular environment and re-balancing the signalling pathways that control the Hair Growth Cycle.

 

Proteoglycan Replacement Therapy works progressively over successive Hair Growth Cycles. Four cycles are illustrated here to demonstrate how the restoration process develops over time. By gradually replenishing key proteoglycans in each of the four cycles, the therapy enhances Wnt signalling – an essential driver of hair growth – while mitigating the inhibitory effects of Dkk1.

2Cycle 2

Proteoglycan Replacement Therapy works progressively over successive Hair Growth Cycles. Four cycles are illustrated here to demonstrate how the restoration process develops over time. By gradually replenishing key proteoglycans in each of the four cycles, the therapy enhances Wnt signalling – an essential driver of hair growth – while mitigating the inhibitory effects of Dkk1.

3Cycle 3

Proteoglycan Replacement Therapy works progressively over successive Hair Growth Cycles. Four cycles are illustrated here to demonstrate how the restoration process develops over time. By gradually replenishing key proteoglycans in each of the four cycles, the therapy enhances Wnt signalling – an essential driver of hair growth – while mitigating the inhibitory effects of Dkk1.

4Cycle 4

The rebalancing of the signalling pathways prolongs the Anagen (growth) phase, delays the transition to Catagen, and shortens the Telogen (resting) phase. The cumulative effect is the restoration of normal follicular function and re-establishment of a healthy Hair Growth Cycle as shown in cycle four.

Stabilising the Hair Growth Signal with Proteoglycan Replacement Therapy

Proteoglycan Replacement Therapy is an intervention that restores proteoglycan levels in the dermal papilla, hereby restoring the structural integrity of the follicular environment and re-balancing the signalling pathways that control the Hair Growth Cycle.

 

As shown in the illustration, Proteoglycan Replacement Therapy works progressively over successive Hair Growth Cycles. Four cycles are illustrated here to demonstrate how the restoration process develops over time. By gradually replenishing key proteoglycans in each of the four cycles, the therapy enhances Wnt signalling – an essential driver of hair growth – while mitigating the inhibitory effects of Dkk1.

 

This rebalancing of signalling pathways prolongs the Anagen (growth) phase, delays the transition to Catagen, and shortens the Telogen (resting) phase. The cumulative effect is the restoration of normal follicular function and re-establishment of a healthy Hair Growth Cycle as shown in cycle four.